The ganglion impar block and prolonged neurolysis are recommended for the treatment of cancer pain in the perineal, vaginal, and rectal areas. The ganglion impar refers to a group of nerve bundles located in front of the lower part of the sacrum. It plays an important role in the regulation of heat and pain. Radiofrequency and chemical neurolysis can inhibit its function and thus reduce pain if the diagnostic block was positive. It typically significantly reduces pain for several years, and the patient can reduce the use of other medications.