{"id":7106,"date":"2025-09-11T14:48:19","date_gmt":"2025-09-11T13:48:19","guid":{"rendered":"https:\/\/fajdalomklinika.hu\/?page_id=7106"},"modified":"2026-03-31T10:34:31","modified_gmt":"2026-03-31T09:34:31","slug":"ketamine-therapy-depression","status":"publish","type":"page","link":"https:\/\/fajdalomklinika.hu\/en\/treatments\/ketamine-therapy-depression\/","title":{"rendered":"Ketamin Therapy for Depression"},"content":{"rendered":"<h1><strong>Ketamine-Assisted Therapy \u2013<\/strong><\/h1>\n<h1><strong>A New Option for Treatment-Resistant Chronic <a href=\"https:\/\/fajdalomklinika.hu\/en\/conditions-we-treat\/depression\/\">Depression<\/a><\/strong><\/h1>\n<p>Ketamine is a medication known for over fifty years and safely used in medical practice, originally as an anesthetic. In recent years, scientific evidence has shown that ketamine-assisted therapy, when applied under controlled medical conditions, offers an evidence-based option for patients whose <a href=\"https:\/\/fajdalomklinika.hu\/en\/conditions-we-treat\/depression\/\">depression<\/a> has not responded to conventional antidepressant treatments<sup>(1,10)<\/sup>. The therapeutic response may vary between individuals; however, studies and clinical experience indicate that improvement can often be observed after just a few sessions. When combined with psychological support\u2014known as ketamine-assisted therapy (KAT)\u2014it may help sustain positive effects and improve long-term outcomes<sup>6<\/sup>.<\/p>\n<h2><strong>Ketamine-Assisted Therapy and Reduction of Suicidal Thoughts<\/strong><\/h2>\n<p>Treatment-resistant depression is often associated with increased suicidal ideation, which requires rapid and effective intervention. Research suggests that ketamine can significantly reduce suicidal thoughts within 24 hours, even when previous treatments have been ineffective<sup>14<\/sup>.<\/p>\n<p>The rapid symptom relief may create a \u201csensitive window,\u201d during which patients are more receptive to therapy, allowing integration sessions to support longer-term stability<sup>5<\/sup>.<\/p>\n<h2><strong>Safety Considerations<\/strong><\/h2>\n<ul>\n<li>Ketamine does not replace acute crisis intervention<\/li>\n<li>Only patients with ensured continuous psychiatric monitoring can be treated<\/li>\n<li>Current evidence suggests that KAT may be a promising adjunctive option for patients with depression and suicidal ideation who have not responded to other therapies<\/li>\n<\/ul>\n<h2><strong>Who May Be Suitable for Ketamine-Assisted Therapy?<\/strong><\/h2>\n<p>The treatment may be recommended for patients who:<\/p>\n<ul>\n<li>have not achieved sustained improvement with at least two different antidepressant medication<sup>13<\/sup>.<\/li>\n<li>suffer from severe, long-standing depression unresponsive to other treatments<sup>8<\/sup>.<\/li>\n<li>in some cases, it may also be used as an adjunct in substance use disorders, as it may reduce cravings and support behavioral change<sup>(7,9)<\/sup>.<\/li>\n<\/ul>\n<h2><strong>How Does Ketamine Work?<\/strong><\/h2>\n<p>Ketamine affects communication between brain cells (synapses), promotes the formation of new connections, and plays a role in mood regulation<sup>(10,11)<\/sup>.<\/p>\n<p>Research shows that:<\/p>\n<ul>\n<li>symptoms may improve within hours<\/li>\n<li>it promotes the rebuilding of neural connections<\/li>\n<li>its effects may last for days or weeks and can be prolonged with repeated treatments<sup>3<\/sup><\/li>\n<\/ul>\n<h2><strong>The Therapeutic Process at Our Clinic<\/strong><\/h2>\n<h3><strong>1. Medical Consultation and Evaluation<\/strong><\/h3>\n<p>The first step is a detailed medical assessment, including:<\/p>\n<ul>\n<li>ECG and laboratory testing<\/li>\n<li>anesthesiology pre-screening<\/li>\n<li>full patient information about the procedure, protocol, and involved specialists<\/li>\n<\/ul>\n<p>Initiation of therapy is the responsibility of a psychiatrist, who also determines patient eligibility.<\/p>\n<h3><strong>2. Psychiatric Consultation<\/strong><\/h3>\n<p>A psychiatric evaluation is required to confirm treatment-resistant depression.<\/p>\n<p>The psychiatrist:<\/p>\n<ul>\n<li>performs a detailed assessment<\/li>\n<li>determines eligibility<\/li>\n<li>coordinates psychological and pharmacological treatment<\/li>\n<\/ul>\n<h3><strong>3. Preparatory Psychological Sessions<\/strong><\/h3>\n<p>Two preparatory psychological sessions precede the first ketamine-assisted treatment. Their goal is to prepare the patient mentally, enhance a sense of safety, and clarify therapeutic goals. Standard questionnaires support the assessment process.<\/p>\n<h3><strong>4. Ketamine-Assisted Therapy Treatment Series<\/strong><\/h3>\n<p>The therapy consists of multiple ketamine infusions administered intravenously under medical supervision. Treatments are individualized and continuously monitored, tailored to the patient\u2019s condition.<\/p>\n<h3><strong>5. Integration Sessions<\/strong><\/h3>\n<p>Each infusion is followed by a short integration discussion, and later by structured therapeutic sessions to help process experiences and reinforce changes.<\/p>\n<h3><strong>6. Follow-up<\/strong><\/h3>\n<p>The process concludes with regular psychiatric and psychological follow-ups to monitor long-term outcomes. The program typically lasts 14\u201318 weeks, based on internationally accepted KAT models<sup>6<\/sup>.<\/p>\n<h2><strong>Safety and Side Effects<\/strong><\/h2>\n<p>Treatments are performed under strict medical supervision by trained professionals.<\/p>\n<h3><strong>After treatment:<\/strong><\/h3>\n<ul>\n<li>patients remain under observation<\/li>\n<li>they must leave with an escort<\/li>\n<li>driving, operating machinery, and alcohol consumption are not allowed for 24 hours<\/li>\n<\/ul>\n<h3><strong>Possible temporary side effects include:<\/strong><\/h3>\n<ul>\n<li>increased blood pressure and heart rate<\/li>\n<li>dizziness, nausea, vomiting<\/li>\n<li>mild dream-like or altered consciousness experiences<sup>(10,11)<\/sup><\/li>\n<li>transient \u201cout-of-body\u201d sensations during infusion<\/li>\n<\/ul>\n<h2><strong>What Makes This Approach Unique?<\/strong><\/h2>\n<ul>\n<li>Rapid effect: symptom improvement may occur within 24 hours<\/li>\n<li>New option: may be effective when other treatments have failed<\/li>\n<li>Integrated approach: the \u201csensitive window\u201d created by ketamine enhances the effectiveness of psychological work and long-term stability<sup>6<\/sup><\/li>\n<li>Also studied as an adjunct in addiction treatment<sup>7<\/sup><\/li>\n<\/ul>\n<h2><strong>Important Information<\/strong><\/h2>\n<ul>\n<li>Ketamine use in psychiatry is currently off-label<\/li>\n<li>Detailed medical information and written consent are required<\/li>\n<li>Treatment can only be performed in a medical setting following strict protocols<\/li>\n<li>Safety is ensured by a multidisciplinary team: psychiatrist, anesthesiologist, psychologist, and MSc-level nursing staff<\/li>\n<\/ul>\n<hr \/>\n<p><em><strong>Source:<\/strong><\/em><\/p>\n<ol>\n<li><em>Sanacora, Gerard, Mark A. Frye, William McDonald, \u00e9s mtsai. \u201eA Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders\u201d.\u00a0JAMA Psychiatry74, sz. 4 (2017): 399.\u00a0<a href=\"https:\/\/doi.org\/10.1001\/jamapsychiatry.2017.0080\">https:\/\/doi.org\/10.1001\/jamapsychiatry.2017.0080<\/a>.<\/em><\/li>\n<li><em>Bahji, Anees, Gustavo H. Vazquez, \u00e9s Carlos A. Zarate. \u201eComparative Efficacy of Racemic Ketamine and Esketamine for Depression: A Systematic Review and Meta-Analysis\u201d.\u00a0Journal of Affective Disorders278 (2021. janu\u00e1r): 542\u201355.\u00a0<a href=\"https:\/\/doi.org\/10.1016\/j.jad.2020.09.071\">https:\/\/doi.org\/10.1016\/j.jad.2020.09.071<\/a>.<\/em><\/li>\n<li><em>Fava, Maurizio, Marlene P. Freeman, Martina Flynn, \u00e9s mtsai. \u201eDouble-Blind, Placebo-Controlled, Dose-Ranging Trial of Intravenous Ketamine as Adjunctive Therapy in Treatment-Resistant Depression (TRD)\u201d.\u00a0Molecular Psychiatry25, sz. 7 (2020): 1592\u2013603.\u00a0<a href=\"https:\/\/doi.org\/10.1038\/s41380-018-0256-5\">https:\/\/doi.org\/10.1038\/s41380-018-0256-5<\/a>.<\/em><\/li>\n<li><em>Morvai Szabolcs, Nagy Attila Istv\u00e1n, B\u00e1lint-Sz\u00f6ll\u0151si Adrienn, M\u00f3r\u00e9 E. Csaba, Berecz Roland, \u00e9s Frecska Ede. \u201eKetamin alkalmaz\u00e1sa s\u00falyos, ter\u00e1piarezisztens depresszi\u00f3s beteg eset\u00e9ben\u201d.\u00a0Ideggy\u00f3gy\u00e1szati Szemle69, sz. 11\u201312 (2016).\u00a0<a href=\"https:\/\/doi.org\/10.18071\/isz.69.0421\">https:\/\/doi.org\/10.18071\/isz.69.0421<\/a>.<\/em><\/li>\n<li><em>Reinstatler, Lael, \u00e9s Nagy A. Youssef. \u201eKetamine as a Potential Treatment for Suicidal Ideation: A Systematic Review of the Literature\u201d.\u00a0Drugs in R&amp;D15, sz. 1 (2015): 37\u201343.\u00a0<a href=\"https:\/\/doi.org\/10.1007\/s40268-015-0081-0\">https:\/\/doi.org\/10.1007\/s40268-015-0081-0<\/a>.<\/em><\/li>\n<li><em>Dore, Jennifer, Brent Turnipseed, Shannon Dwyer, \u00e9s mtsai. \u201eKetamine Assisted Psychotherapy (KAP): Patient Demographics, Clinical Data and Outcomes in Three Large Practices Administering Ketamine with Psychotherapy\u201d.\u00a0Journal of Psychoactive Drugs51, sz. 2 (2019): 189\u201398.\u00a0<a href=\"https:\/\/doi.org\/10.1080\/02791072.2019.1587556\">https:\/\/doi.org\/10.1080\/02791072.2019.1587556<\/a>.<\/em><\/li>\n<li><em>Das, Ravi K., Grace Gale, Katie Walsh, \u00e9s mtsai. \u201eKetamine Can Reduce Harmful Drinking by Pharmacologically Rewriting Drinking Memories\u201d.\u00a0Nature Communications10, sz. 1 (2019): 5187.\u00a0<a href=\"https:\/\/doi.org\/10.1038\/s41467-019-13162-w\">https:\/\/doi.org\/10.1038\/s41467-019-13162-w<\/a>.<\/em><\/li>\n<li><em>Andrade, Chittaranjan. \u201eKetamine for Depression, 4: In What Dose, at What Rate, by What Route, for How Long, and at What Frequency?\u201d:\u00a0The Journal of Clinical Psychiatry78, sz. 7 (2017): e852\u201357.\u00a0<a href=\"https:\/\/doi.org\/10.4088\/JCP.17f11738\">https:\/\/doi.org\/10.4088\/JCP.17f11738<\/a>.<\/em><\/li>\n<li><em>Kolp, Eli, Harris L. Friedman, University of Florida, \u00e9s mtsai. \u201eKetamine Psychedelic Psychotherapy: Focus on Its Pharmacology, Phenomenology, and Clinical Applications\u201d.\u00a0International Journal of Transpersonal Studies33, sz. 2 (2014): 84\u2013140.\u00a0<a href=\"https:\/\/doi.org\/10.24972\/ijts.2014.33.2.84\">https:\/\/doi.org\/10.24972\/ijts.2014.33.2.84<\/a>.<\/em><\/li>\n<li><em>Yavi, Mani, Holim Lee, Ioline D. Henter, Lawrence T. Park, \u00e9s Carlos A. Zarate. \u201eKetamine Treatment for Depression: A Review\u201d.\u00a0Discover Mental Health2, sz. 1 (2022): 9.\u00a0<a href=\"https:\/\/doi.org\/10.1007\/s44192-022-00012-3\">https:\/\/doi.org\/10.1007\/s44192-022-00012-3<\/a>.<\/em><\/li>\n<li><em>Underwood, Emily. \u201eListening to Ketamine\u201d.\u00a0Knowable Magazine, advance online publication, 2019. m\u00e1rcius 29.\u00a0<a href=\"https:\/\/doi.org\/10.1146\/knowable-032819-1\">https:\/\/doi.org\/10.1146\/knowable-032819-1<\/a>.<\/em><\/li>\n<li><em>Taraku, Brandon, Joana R. Loureiro, Ashish K. Sahib, \u00e9s mtsai. \u201eModulation of Habenular and Nucleus Accumbens Functional Connectivity by Ketamine in Major Depression\u201d.\u00a0Brain and Behavior14, sz. 6 (2024): e3511.\u00a0<a href=\"https:\/\/doi.org\/10.1002\/brb3.3511\">https:\/\/doi.org\/10.1002\/brb3.3511<\/a>.<\/em><\/li>\n<li><em>Yeung, Albert, Guy Sapirstein, Laura D. Crain, Margaret A. Cramer, \u00e9s Fernando Espi Forcen. \u201ePharmacotherapy and Ketamine Assisted Psychotherapy for Treatment-Resistant Depression: A Patient With Lifelong Self-Doubt and Self-Criticism\u201d.\u00a0The Journal of Clinical Psychiatry84, sz. 3 (2023).\u00a0<a href=\"https:\/\/doi.org\/10.4088\/JCP.23ct14798\">https:\/\/doi.org\/10.4088\/JCP.23ct14798<\/a>.<\/em><\/li>\n<li><em>Wilkinson, Samuel T., Elizabeth D. Ballard, Michael H. Bloch, \u00e9s mtsai. \u201eThe Effect of a Single Dose of Intravenous Ketamine on Suicidal Ideation: A Systematic Review and Individual Participant Data Meta-Analysis\u201d.\u00a0American Journal of Psychiatry175, sz. 2 (2018): 150\u201358.\u00a0<a href=\"https:\/\/doi.org\/10.1176\/appi.ajp.2017.17040472\">https:\/\/doi.org\/10.1176\/appi.ajp.2017.17040472<\/a>.<\/em><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Ketamine-Assisted Therapy \u2013 A New Option for Treatment-Resistant Chronic Depression Ketamine is a medication known for over fifty years and safely used in medical practice, originally as an anesthetic. In&#8230;<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":233,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-sidebar.php","meta":{"footnotes":""},"class_list":["post-7106","page","type-page","status-publish"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Ketamin Therapy for Depression | F\u00e1jdalomklinika<\/title>\n<meta name=\"description\" content=\"Ketamine-assisted therapy helps reduce treatment-resistant depression and supports recovery under medical supervision.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fajdalomklinika.hu\/en\/treatments\/ketamine-therapy-depression\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" 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